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OSTEOCLASTOGENESIS INHIBITORY FACTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Osteoprotegerin
Descriptor
Spanish
:
Osteoprotegerina
Descriptor
Portuguese
:
Osteoprotegerina
Synonyms
English
:
Osteoclastogenesis Inhibitory Factor
Receptors, Tumor Necrosis Factor, Member 11b
Tumor Necrosis Factor Receptor Superfamily, Member 11b
Tree Number:
D12.776.543.750.705.852.760.949.249
Definition
English
:
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of
RANK LIGAND
that inhibits both
CELL DIFFERENTIATION
and function of
OSTEOCLASTS
by inhibiting the interaction between
RANK LIGAND
and
RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B
.
History Note
English
:
2007(1997)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52396
Unique Identifier:
D053244
Occurrence in VHL
:
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